Neurodegenerative disease: Diabetes, microvascular pathology and Alzheimer disease
- PMID: 19498432
- DOI: 10.1038/nrneurol.2009.72
Neurodegenerative disease: Diabetes, microvascular pathology and Alzheimer disease
Abstract
Epidemiological studies suggest that the risk of developing cognitive impairment and dementia is increased in individuals with diabetes mellitus, although the evidence from clinicopathological studies on neurodegenerative changes is at odds with these observations. A thorough appraisal of concomitant vascular changes in dementia might resolve this incongruity.
Comment on
-
Different patterns of cerebral injury in dementia with or without diabetes.Arch Neurol. 2009 Mar;66(3):315-22. doi: 10.1001/archneurol.2008.579. Epub 2009 Jan 12. Arch Neurol. 2009. PMID: 19139294 Free PMC article.
Similar articles
-
Beta-amyloid pathology in human brain microvessel extracts from the parietal cortex: relation with cerebral amyloid angiopathy and Alzheimer's disease.Acta Neuropathol. 2019 May;137(5):801-823. doi: 10.1007/s00401-019-01967-4. Epub 2019 Feb 7. Acta Neuropathol. 2019. PMID: 30729296 Free PMC article.
-
Interhemispheric distribution of Alzheimer disease and vascular pathology in brain aging.Stroke. 2009 Mar;40(3):983-6. doi: 10.1161/STROKEAHA.108.530337. Epub 2008 Dec 31. Stroke. 2009. PMID: 19118241 Free PMC article.
-
Cognitive impairment with vascular impairment and degeneration.Curr Neurovasc Res. 2011 Nov;8(4):342-50. doi: 10.2174/156720211798120981. Curr Neurovasc Res. 2011. PMID: 22023618 Review.
-
Small vessel disease pathological changes in neurodegenerative and vascular dementias concomitant with autonomic dysfunction.Brain Pathol. 2020 Jan;30(1):191-202. doi: 10.1111/bpa.12769. Epub 2019 Aug 16. Brain Pathol. 2020. PMID: 31357238 Free PMC article.
-
The hippocampus in neurodegenerative disease.Front Neurol Neurosci. 2014;34:95-108. doi: 10.1159/000356430. Epub 2014 Apr 16. Front Neurol Neurosci. 2014. PMID: 24777134 Review.
Cited by
-
Protective Effect of Topiramate on Hyperglycemia-Induced Cerebral Oxidative Stress, Pericyte Loss and Learning Behavior in Diabetic Mice.Int Libr Diabetes Metab. 2015 Mar;1(1):6-12. Int Libr Diabetes Metab. 2015. PMID: 26120599 Free PMC article.
-
Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes.J Pathol. 2011 Sep;225(1):54-62. doi: 10.1002/path.2912. Epub 2011 May 19. J Pathol. 2011. PMID: 21598254 Free PMC article.
-
Diabetes negatively affects cortical and striatal GABAergic neurons: an effect that is partially counteracted by exendin-4.Biosci Rep. 2016 Dec 5;36(6):e00421. doi: 10.1042/BSR20160437. Print 2016 Dec. Biosci Rep. 2016. PMID: 27780892 Free PMC article.
-
Vascular β-amyloid and early astrocyte alterations impair cerebrovascular function and cerebral metabolism in transgenic arcAβ mice.Acta Neuropathol. 2011 Sep;122(3):293-311. doi: 10.1007/s00401-011-0834-y. Epub 2011 Jun 19. Acta Neuropathol. 2011. PMID: 21688176 Free PMC article.
-
Diabetic Kinome Inhibitors-A New Opportunity for β-Cells Restoration.Int J Mol Sci. 2021 Aug 23;22(16):9083. doi: 10.3390/ijms22169083. Int J Mol Sci. 2021. PMID: 34445786 Free PMC article. Review.
References
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical