Pain: Do ACE inhibitors exacerbate complex regional pain syndrome?
- PMID: 19498433
- DOI: 10.1038/nrneurol.2009.73
Pain: Do ACE inhibitors exacerbate complex regional pain syndrome?
Abstract
Complex regional pain syndrome is a chronic condition arising mainly after tissue injury and involves both inflammatory and neurogenic factors. Use of angiotensin-converting-enzyme inhibitors has been associated with an increased risk of developing the chronic pain condition, which suggests possible roles for substance P and bradykinin in the underlying pathogenic process.
Comment on
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The association between ACE inhibitors and the complex regional pain syndrome: Suggestions for a neuro-inflammatory pathogenesis of CRPS.Pain. 2009 Apr;142(3):218-224. doi: 10.1016/j.pain.2008.12.032. Epub 2009 Feb 4. Pain. 2009. PMID: 19195784
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