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. 2002 Jun;13(2):56-61.

A fundamental introduction to ion mobility mass spectrometry applied to the analysis of biomolecules

Guido F Verbeck  1 , Brandon T Ruotolo, Holly A Sawyer, Kent J Gillig, David H Russell
Affiliations

A fundamental introduction to ion mobility mass spectrometry applied to the analysis of biomolecules

Guido F Verbeck et al. J Biomol Tech. 2002 Jun.

Abstract

Chemists are constantly striving for techniques that add dimensions of orthogonality with increased throughput and sample complexity. Ion mobility spectrometry (IM) is a gas-phase separation method that adds new dimensions to mass spectrometry (MS). IM separates gas-phase ions based on their collision cross-section and can be coupled with time-of-flight (TOF) mass spectrometry to yield a powerful tool used in the identification and characterization of proteins and peptides. A fundamental introduction to IM is presented with a focus on resolution, sensitivity, and orthogonality coupled with TOF-MS.

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