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Review
. 2009 Oct;10(5):317-25.
doi: 10.1007/s10194-009-0130-6. Epub 2009 Jun 5.

Migraine pain: reflections against vasodilatation

Alessandro Panconesi  1 , Maria Letizia Bartolozzi, Leonello Guidi
Affiliations
Review

Migraine pain: reflections against vasodilatation

Alessandro Panconesi et al. J Headache Pain. 2009 Oct.

Abstract

The original Wolff's vascular theory of migraine was supported by the discovery of a class of drugs, the triptans, developed as a selective cephalic vasoconstrictor agents. Even in the neurovascular hypothesis of Moskowitz, that is the neurogenic inflammation of meningeal vessels provoked by peptides released from trigeminal sensory neurons, the vasodilatation provoked by calcitonin gene-related peptide (CGRP) is considered today much more important than oedema. The role of cephalic vasodilatation as a cause of migraine pain was recently sustained by studies showing the therapeutic effect of CGRP receptor antagonists. We discuss the evidence against vasodilatation as migraine pain generator and some findings which we suggest in support of a central (brain) origin of pain.

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