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. 2009 Jul;12(7):823-5.
doi: 10.1038/nn.2329. Epub 2009 Jun 7.

betaCaMKII controls the direction of plasticity at parallel fiber-Purkinje cell synapses

Geeske M van Woerden  1 , Freek E Hoebeek, Zhenyu Gao, Raghavendra Y Nagaraja, Casper C Hoogenraad, Steven A Kushner, Christian Hansel, Chris I De Zeeuw, Ype Elgersma
Affiliations

betaCaMKII controls the direction of plasticity at parallel fiber-Purkinje cell synapses

Geeske M van Woerden et al. Nat Neurosci. 2009 Jul.

Abstract

We found that betaCaMKII, the predominant CaMKII isoform of the cerebellum, is important for controlling the direction of plasticity at the parallel fiber-Purkinje cell synapse; a protocol that induced synaptic depression in wild-type mice resulted in synaptic potentiation in Camk2b knockout mice and vice versa. These findings provide us with unique experimental insight into the mechanisms that transduce graded calcium signals into either synaptic depression or potentiation.

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