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. 2009 Sep;14(6):388-94.
doi: 10.1080/13547500903015784.

S100B and brain natriuretic peptide predict functional neurological outcome after intracerebral haemorrhage

Michael L James  1 , Robert Blessing, Barbara G Phillips-Bute, Ellen Bennett, Daniel T Laskowitz
Affiliations

S100B and brain natriuretic peptide predict functional neurological outcome after intracerebral haemorrhage

Michael L James et al. Biomarkers. 2009 Sep.

Abstract

Objective: To determine the predictive value of S100b and brain natriuretic peptide (BNP) in order to determine accurately and quickly a discharge prognosis after primary supratentorial intracerebral haemorrhage (ICH).

Methods: After IRB approval and informed consent, blood samples were obtained and analysed from 28 adult patients consecutively admitted to the neuroscience intensive care unit with computed tomography-proven supratentorial ICH from June 2003 and December 2004 within the first 24 h after symptom onset for S100b and BNP. Functional outcomes on discharge were dichotomized to favourable (mRS < 3) or unfavourable.

Results: BNP (a neurohormone) and S100b (a marker of glial activation) were found to be independently highly predictive of functional neurological outcome at the time of discharge as measured by the modified Rankin Score (BNP: p < 0.01, r = 0.46; S100b: p < 0.01, r = 0.42) and the Barthel Index (BNP: p < 0.01, r = 0.54; s100b: p < 0.01, r = 0.50). Although inclusion of either biomarker produced additive value when included with traditional clinical prognostic variables, such as the ICH score (Barthel index: p < 0.01, r = 0.66; mRS: p < 0.01, r = 0.96), little predictive power is added with inclusion of both biomarkers in a regression model for neurological outcome.

Conclusions: Serum S100b and BNP levels in the first 24 h after injury accurately predict neurological function at discharge after supratentorial ICH.

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References

    1. Abstracts of the Neurocritical Care Society 6th Annual Meeting. October 23-25, 2008. Miami, Florida, USA. Neurocrit Care. 2008;9(Suppl):S3–196. - PubMed
    1. ABILLEIRA S, MONTANER J, MOLINA CA, MONASTERIO J, CASTILLO J, ALVAREZ-SABIN J. Matrix metalloproteinase-9 concentration after spontaneous intracerebral hemorrhage. J Neurosurg. 2003;99:65–70. - PubMed
    1. ABRAHA HD, BUTTERWORTH RJ, BATH PM, WASSIF WS, GARTHWAITE J, SHERWOOD RA. Serum S-100 protein, relationship to clinical outcome in acute stroke. Ann Clin Biochem. 1997;34(Pt 4):366–70. - PubMed
    1. AKDEMIR G, LUER MS, DUJOVNY M, MISRA M. Intraventricular atrial natriuretic peptide for acute intracranial hypertension. Neurol Res. 1997;19:515–20. - PubMed
    1. ALLARD L, LESCUYER P, BURGESS J, LEUNG KY, WARD M, WALTER N, BURKHARD PR, CORTHALS G, HOCHSTRASSER DF, SANCHEZ JC. ApoC-I and ApoC-III as potential plasmatic markers to distinguish between ischemic and hemorrhagic stroke. Proteomics. 2004;4:2242–51. - PubMed

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