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Review
. 2009 Jun-Aug;1789(6-8):443-50.
doi: 10.1016/j.bbagrm.2009.05.007. Epub 2009 Jun 6.

Sin3: master scaffold and transcriptional corepressor

Adrienne Grzenda  1 , Gwen Lomberk, Jin-San Zhang, Raul Urrutia
Affiliations
Review

Sin3: master scaffold and transcriptional corepressor

Adrienne Grzenda et al. Biochim Biophys Acta. 2009 Jun-Aug.

Abstract

Sin3 was isolated over two decades ago as a negative regulator of transcription in budding yeast. Subsequent research has established the protein as a master transcriptional scaffold and corepressor capable of transcriptional silencing via associated histone deacetylases (HDACs). The core Sin3-HDAC complex interacts with a wide variety of repressors and corepressors, providing flexibility and expanded specificity in modulating chromatin structure and transcription. As a result, the Sin3/HDAC complex is involved in an array of biological and cellular processes, including cell cycle progression, genomic stability, embryonic development, and homeostasis. Abnormal recruitment of this complex or alteration of its enzymatic activity has been implicated in neoplastic transformation.

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Figures

Figure 1
Figure 1
The Sin3 protein is 1536 amino acids in length, possessing six highly conserved regions.
See this image and copyright information in PMC

References

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