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Review
. 2009 Aug;19(4):244-51.
doi: 10.1016/j.semcancer.2009.02.003. Epub 2009 Feb 14.

Immunity to polyomavirus infection: the polyomavirus-mouse model

Phillip A Swanson 2nd  1 , Aron E Lukacher, Eva Szomolanyi-Tsuda
Affiliations
Review

Immunity to polyomavirus infection: the polyomavirus-mouse model

Phillip A Swanson 2nd et al. Semin Cancer Biol. 2009 Aug.

Abstract

A ubiquitous clinically silent murine pathogen, polyomavirus has enjoyed long-term co-evolution with the mouse, a highly tractable and genetically and immunologically informative small animal model. Thus, polyomavirus has provided a valuable experimental construct to decipher the host immune mechanisms that come into play to control systemic low-level persistent viral infections. Impaired immunosurveillance for infected cells puts the murine host at risk both to injury resulting from excessive direct virus cytolysis and development of virus-induced tumors. In this review, we present our current understanding of the multifaceted immune response invoked by the mouse to maintain détente with this potentially deleterious persistent natural pathogen, and discuss implications of these studies for therapeutic interventions for human polyomavirus infection.

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