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Review
. 2009 Jun;18(6):1680-7.
doi: 10.1158/1055-9965.EPI-09-0006.

Apoptosis in the colonic crypt, colorectal adenomata, and manipulation by chemoprevention

Nicholas J West  1 , Edward D J Courtney, Andrew P Poullis, Roger J Leicester
Affiliations
Review

Apoptosis in the colonic crypt, colorectal adenomata, and manipulation by chemoprevention

Nicholas J West et al. Cancer Epidemiol Biomarkers Prev. 2009 Jun.

Abstract

This review discusses the biology and the methods of assessment of apoptosis, of which, the monoclonal antibody M30 would seem to be the most useful; the role of apoptosis in the etiology of colorectal cancer; and its use as a marker to monitor the beneficial effects of chemopreventative interventions to reduce the development of colorectal cancer within the context of clinical trials.

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