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. 2009 Jun;72(6):1216-9.
doi: 10.1021/np800726d.

Ammonificins A and B, hydroxyethylamine chroman derivatives from a cultured marine hydrothermal vent bacterium, Thermovibrio ammonificans

Eric H Andrianasolo  1 , Liti Haramaty, Richard Rosario-Passapera, Kelly Bidle, Eileen White, Costantino Vetriani, Paul Falkowski, Richard Lutz
Affiliations

Ammonificins A and B, hydroxyethylamine chroman derivatives from a cultured marine hydrothermal vent bacterium, Thermovibrio ammonificans

Eric H Andrianasolo et al. J Nat Prod. 2009 Jun.

Abstract

Two hydroxyethylamine chroman derivatives, ammonificins A (1) and B (2), were isolated from the marine hydrothermal vent bacterium Thermovibrio ammonificans. The molecular structures of these compounds were determined using a combination of NMR, mass spectrometry, and CD analyses. Biological activities were determined using an antimicrobial assay and the patented ApopScreen cell-based screen for apoptosis induction and potential anticancer activity. To our knowledge, this is the first report of secondary metabolites from the marine hydrothermal vent bacterium T. ammonificans.

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Figures

Figure 1
Figure 1
Key HMBC and selected COSY correlations for ammonificin A (1).
Figure 2
Figure 2
Comparison of the experimental CD spectrum (—) of 1 with the spectra calculated (•••) for 3S, 4S,9R.
Figure 3
Figure 3
Comparison of the experimental CD spectrum (—) of 2 with the spectra calculated (•••) for 3S, 4S,9R.
See this image and copyright information in PMC

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