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. 2009 Sep;98(9):1521-5.
doi: 10.1111/j.1651-2227.2009.01349.x. Epub 2009 Jun 8.

Effects of topiramate on weight and metabolism in children with epilepsy

Hai-feng Li  1 , Yan Zou, Zhe-zhi Xia, Feng Gao, Jian-hua Feng, Cui-wei Yang
Affiliations

Effects of topiramate on weight and metabolism in children with epilepsy

Hai-feng Li et al. Acta Paediatr. 2009 Sep.

Abstract

Aim: To explore the mechanism of topiramate-induced weight loss in epilepsy children by monitoring metabolism indices.

Methods: Children with epilepsy were treated with topiramate at their first clinical visit. Metabolism indices including body mass index (BMI) and its SD scores, leptin, adiponectin, leptin/adiponectin (L/A), lipid profile-insulin and Homeostasis Model Assessments (HOMA) index were collected before and after treatment.

Results: Topiramate treatment significantly reduced L/A (t = 2.156, p = 0.031), and markedly increased the serum level of adiponectin (t = 3.124, p = 0.002). Moreover, there were no relationships between the metabolism indices and dosages of topiramate (p > 0.05).

Conclusion: Our studies find that topiramate treatment in epilepsy children increases energy metabolism, resulting in weight loss. It has been demonstrated that adiponectin play a significant role in metabolic regulations.

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