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. 1977 Jun;22(3):750-7.
doi: 10.1128/JVI.22.3.750-757.1977.

Cell-free synthesis of herpes simplex virus proteins

K J Cremer, W C Summers, R F Gesteland

Cell-free synthesis of herpes simplex virus proteins

K J Cremer et al. J Virol. 1977 Jun.

Abstract

Polyribosomes isolated from herpes simplex virus type I (HSV-1)-infected cells have been used to program a eucaryotic cell-free translation system. At least 10 HSV-specific polypeptides, with apparent molecular weights of 25,000 to 160,000, are synthesized by wild-type HSV-infected polyribosomes. Polyribosomes prepared from thymidine kinase-negative mutants of HSV direct the synthesis of three putative nonsense termination polypeptides. HSV-specific polypeptides synthesized in vitro are precipitated with antiserum to HSV-infected cell proteins.

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References

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