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Review
. 2009 Jun:24:186-91.
doi: 10.1152/physiol.00005.2009.

Hypertonic stress in the kidney: a necessary evil

Min Seong Kwon  1 , Sun Woo Lim, H Moo Kwon
Affiliations
Free article
Review

Hypertonic stress in the kidney: a necessary evil

Min Seong Kwon et al. Physiology (Bethesda). 2009 Jun.
Free article

Abstract

The interstitium of the renal medulla is hypertonic, imposing deleterious effects on local cells. At the same time, the hypertonicity provides osmotic gradient for water reabsorption and is a local signal for tissue-specific gene expression and differentiation of the renal medulla, which is a critical organ for water homeostasis.

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