Comment
doi: 10.1158/1078-0432.CCR-09-0552.
Epub 2009 Jun 9.
Tissue targeting in cancer: eIF4E's tale
Affiliations
- PMID: 19509132
- DOI: 10.1158/1078-0432.CCR-09-0552
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Comment
Tissue targeting in cancer: eIF4E's tale
Clin Cancer Res.
.
Abstract
The eukaryotic translation initiation factor eIF4E is elevated in many human cancers. Tissue-specific targeting of eIF4E activity in ovarian cancer cells is achieved in cell culture and in mice by fusing a peptide corresponding to the eIF4E inhibitor, the eIF4E binding protein 1 (BP1), to an agonist of the gonadotropin receptor.
Comment on
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Inhibition of ovarian cancer growth by a tumor-targeting peptide that binds eukaryotic translation initiation factor 4E.Clin Cancer Res. 2009 Jul 1;15(13):4336-47. doi: 10.1158/1078-0432.CCR-08-2924. Epub 2009 May 19. Clin Cancer Res. 2009. PMID: 19458052
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