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Comment
. 2009 Jun 15;15(12):3906-7.
doi: 10.1158/1078-0432.CCR-09-0572. Epub 2009 Jun 9.

Toward an effective targeted chemotherapy for multiple myeloma

Andrew G Polson  1 , Mark X Sliwkowski
Affiliations
Comment

Toward an effective targeted chemotherapy for multiple myeloma

Andrew G Polson et al. Clin Cancer Res. .

Abstract

Antibody-drug conjugates (ADCs), cytotoxic drugs chemically linked to antibodies, provide a means to increase the effectiveness of chemotherapy by targeting the drug to neoplastic cells. Anti-CD138 ADCs show promising preclinical efficacy for the treatment of multiple myeloma; however, the safety aspects of targeting CD138 have yet to be explored.

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