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Review
. 2009 Jul;19(7):559-62.
doi: 10.1097/FPC.0b013e32832e0e97.

Cytochrome P450 2D6

Ryan P Owen  1 , Katrin Sangkuhl, Teri E Klein, Russ B Altman
Affiliations
Review

Cytochrome P450 2D6

Ryan P Owen et al. Pharmacogenet Genomics. 2009 Jul.
No abstract available

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References

    1. Ingelman-Sundberg M, Sim SC, Gomez A, Rodriguez-Antona C. Influence of cytochrome P450 polymorphisms on drug therapies: pharmacogenetic, pharmacoepigenetic and clinical aspects. Pharmacol Ther. 2007;116:496–526. - PubMed
    1. Mahgoub A, Idle JR, Dring LG, Lancaster R, Smith RL. Polymorphic hydroxylation of debrisoquine in man. Lancet. 1977;2:584–586. - PubMed
    1. Eichelbaum M, Spannbrucker N, Steincke B, Dengler HJ. Defective N-oxidation of sparteine in man: a new pharmacogenetic defect. Eur J Clin Pharmacol. 1979;16:183–187. - PubMed
    1. Evans DA, Harmer D, Downham DY, Whibley EJ, Idle JR, Ritchie J, Smith RL. The genetic control of sparteine and debrisoquine metabolism in man with new methods of analysing bimodal distributions. J Med Genet. 1983;20:321–329. - PMC - PubMed
    1. Distlerath LM, Reilly PE, Martin MV, Davis GG, Wilkinson GR, Guengerich FP. Purification and characterization of the human liver cytochromes P-450 involved in debrisoquine 4-hydroxylation and phenacetin O-deethylation, two prototypes for genetic polymorphism in oxidative drug metabolism. J Biol Chem. 1985;260:9057–9067. - PubMed

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