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. 2007 Jun;3(2):116-9.
doi: 10.3988/jcn.2007.3.2.116. Epub 2007 Jun 20.

Polyneuropathy associated with IgA paraproteinemia and amyloidosis: a case report and literature review

Yunsook Jhang  1 , Jung Ju Lee, Jong-Moo Park, Ja-Seong Koo, Byung-Kun Kim, Ohyun Kwon
Affiliations

Polyneuropathy associated with IgA paraproteinemia and amyloidosis: a case report and literature review

Yunsook Jhang et al. J Clin Neurol. 2007 Jun.

Abstract

Paraproteinemia potentially causes peripheral neuropathy via an unknown underlying pathogenetic mechanism. We report a case of pathologically proven amyloid neuropathy with AL amyloidosis with an IgA kappa light chain, which was initially diagnosed as neuropathy associated with monoclonal gammopathy of undetermined significance. This case indicates that in cases of neuropathy with paraproteinemia, the other potential causes should be excluded by appropriate means, especially pathological evaluations.

Keywords: Amyloidosis; Paraproteinemia; Polyneuropathy.

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Figures

Figure 1
Figure 1
Deposition of amorphous materials in the endoneurium was indicated in sections stained with H&E (A) that exhibited birefringence under polarized-light microscopy with Congo red staining (B, arrows).
Figure 2
Figure 2
Ultrastructural examination showed that both myelinated and unmyelinated fibers had nonbranching amyloid fibrils in a haphazard arrangement in the endoneurium.
See this image and copyright information in PMC

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