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. 2009;28(1):23-4.
doi: 10.1080/15569520802636082.

Safety of a preservative system containing 1,2-hexanediol and caprylyl glycol

Stanley B Levy  1 , Anthony M Dulichan, Michael Helman
Affiliations

Safety of a preservative system containing 1,2-hexanediol and caprylyl glycol

Stanley B Levy et al. Cutan Ocul Toxicol. 2009.

Abstract

To study the potential for delayed Type IV dermal sensitivity of a new preservative system containing 1,2-hexanediol and caprylyl glycol, 200-subject repeat insult patch tests were performed with a 15% mixture of 1,2-hexanediol and caprylyl glycol (equal parts of the 2 ingredients) in carbomer gel and a cosmetic formulation at an actual use concentration. No delayed Type IV hypersensitivity reactions were observed.

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