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. 2009 Aug 1;19(15):4280-3.
doi: 10.1016/j.bmcl.2009.05.071. Epub 2009 May 27.

Dipeptidyl nitrile inhibitors of Cathepsin L

Nabil Asaad  1 , Paul A Bethel, Michelle D Coulson, Jack E Dawson, Susannah J Ford, Stefan Gerhardt, Matthew Grist, Gordon A Hamlin, Michael J James, Emma V Jones, Galith I Karoutchi, Peter W Kenny, Andrew D Morley, Keith Oldham, Neil Rankine, David Ryan, Stuart L Wells, Linda Wood, Martin Augustin, Stephan Krapp, Hannes Simader, Stefan Steinbacher
Affiliations

Dipeptidyl nitrile inhibitors of Cathepsin L

Nabil Asaad et al. Bioorg Med Chem Lett. .

Abstract

A series of potent Cathepsin L inhibitors with good selectivity with respect to other cysteine Cathepsins is described and SAR is discussed with reference to the crystal structure of a protein-ligand complex.

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