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Clinical Trial
. 2009 Sep;40(9):3086-90.
doi: 10.1161/STROKEAHA.109.550889. Epub 2009 Jun 11.

Single limb exercise induces femoral artery remodeling and improves blood flow in the hemiparetic leg poststroke

Sandra A Billinger  1 , Byron J Gajewski, Lisa X Guo, Patricia M Kluding
Affiliations
Clinical Trial

Single limb exercise induces femoral artery remodeling and improves blood flow in the hemiparetic leg poststroke

Sandra A Billinger et al. Stroke. 2009 Sep.

Abstract

Background and purpose: After stroke, individuals have decreased mobility of the hemiparetic leg, which demands less muscle oxygen consumption; thus, blood flow decreases. The purpose of this study was to determine the effect of single limb exercise (SLE) on femoral artery blood flow, diameter, and peak flow velocity in the hemiparetic leg after stroke.

Methods: Twelve individuals (60.6+/-14.5 years of age; 5 male) with chronic stroke (69.1+/-82.2 months; 5 with right-sided hemiparesis) participated in the study. The intervention consisted of a SLE knee extension/flexion protocol 3 times per week for 4 weeks. Using Doppler ultrasound, bilateral femoral artery blood flow, diameter, and peak flow velocity were assessed at baseline, after 2 weeks, and after 4 weeks of SLE.

Results: Using repeated-measures analysis of variance, femoral artery blood flow, arterial diameter, and blood flow velocity in the hemiparetic limb were significantly improved (P<0.0001) after the SLE. No significant changes occurred in the nontrained limb for any outcome measures.

Conclusions: These data suggest that a 4-week SLE training program that increases muscular activity in the hemiparetic limb improves femoral artery blood flow, diameter, and peak velocity. SLE may be an important training strategy in stroke rehabilitation to minimize the vascular changes that occur poststroke due to decreased activity of the hemiparetic limb.

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Figures

Figure 1
Figure 1
Femoral Artery Blood Flow Over the Intervention *T1 = 2 weeks; Post = 4 weeks
Figure 2
Figure 2
Femoral Artery Diameter Over the Intervention *T1 = 2 weeks; Post = 4 weeks
See this image and copyright information in PMC

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