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. 2009 Nov;20(11):2349-52.
doi: 10.1007/s10856-009-3794-1. Epub 2009 Jun 12.

Immobilization of RGD peptide on HA coating through a chemical bonding approach

Chunli Yang  1 , Kui Cheng, Wenjian Weng, Chunyu Yang
Affiliations

Immobilization of RGD peptide on HA coating through a chemical bonding approach

Chunli Yang et al. J Mater Sci Mater Med. 2009 Nov.

Abstract

In this work, Arg-Gly-Asp (RGD) sequence containing peptide was immobilized on hydroxyapatite (HA) coatings through a chemical bonding approach in two steps, surface modification with 3-aminopropyltriethoxysilane (APTES) and RGD immobilization. The results indicate that RGD has been successfully immobilized on HA coatings. Comparing with physical adsorption coatings, the chemically bonded RGD on the coatings shows much better anti-wash-out ability. Since RGD is able to recognize cell-membrane integrins on biointerfaces, the present method will be an effective way to favor interaction of cells with HA coatings.

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