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. 2009 Jun 14;15(22):2748-53.
doi: 10.3748/wjg.15.2748.

Pre-endoscopic screening for Helicobacter pylori and celiac disease in young anemic women

Lucy Vannella  1 , Debora Gianni, Edith Lahner, Antonio Amato, Enzo Grossi, Gianfranco Delle Fave, Bruno Annibale
Affiliations

Pre-endoscopic screening for Helicobacter pylori and celiac disease in young anemic women

Lucy Vannella et al. World J Gastroenterol. .

Abstract

Aim: To evaluate the usefulness of pre-endoscopic serological screening for Helicobacter pylori (H pylori) infection and celiac disease in women aged < 50 years affected by iron-deficiency anemia (IDA).

Methods: One hundred and fifteen women aged < 50 years with IDA were tested by human recombinant tissue transglutaminase IgA antibodies (tTG) and anti-H pylori IgG antibodies. tTG and H pylori IgG antibody were assessed using an enzyme-linked immunosorbent assay (ELISA). All women were invited to undergo upper GI endoscopy. During gastroscopy, biopsies were collected from antrum (n = 3), gastric body (n = 3) and duodenum (n = 4) in all patients, irrespective of test results. The assessment of gastritis was performed according to the Sydney system and celiac disease was classified by Marsh's System.

Results: 45.2% women were test-positive: 41 patients positive for H pylori antibodies, 9 patients for tTG and 2 patients for both. The gastroscopy compliance rate of test-positive women was significantly increased with respect to those test-negative (65.4% vs 42.8%; Fisher test P = 0.0239). The serological results were confirmed by gastroscopy in 100% of those with positive H pylori antibodies, in 50% of those with positive tTG and in 81.5% of test-negative patient. Sensitivity and specificity were 84.8% and 100%, respectively for H pylori infection and, 80% and 92.8% for tTG. Twenty-eight patients had positive H pylori antibodies and in all the patients, an active H pylori infection was found. In particular, in 23 out of 28 (82%) patients with positive H pylori antibodies, a likely cause of IDA was found because of the active inflammation involving the gastric body.

Conclusion: Anti-H pylori IgG antibody and tTG IgA antibody testing is able to select women with IDA to submit for gastroscopy to identify H pylori pangastritis and/or celiac disease, likely causes of IDA.

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Figures

Figure 1
Figure 1
Study population. n: Numbers of patients.
See this image and copyright information in PMC

References

    1. Looker AC, Dallman PR, Carroll MD, Gunter EW, Johnson CL. Prevalence of iron deficiency in the United States. JAMA. 1997;277:973–976. - PubMed
    1. El-Hemaidi I, Gharaibeh A, Shehata H. Menorrhagia and bleeding disorders. Curr Opin Obstet Gynecol. 2007;19:513–520. - PubMed
    1. Bini EJ, Micale PL, Weinshel EH. Evaluation of the gastrointestinal tract in premenopausal women with iron deficiency anemia. Am J Med. 1998;105:281–286. - PubMed
    1. Fireman Z, Zachlka R, Abu Mouch S, Kopelman Y. The role of endoscopy in the evaluation of iron deficiency anemia in premenopausal women. Isr Med Assoc J. 2006;8:88–90. - PubMed
    1. Vannella L, Aloe Spiriti MA, Cozza G, Tardella L, Monarca B, Cuteri A, Moscarini M, Delle Fave G, Annibale B. Benefit of concomitant gastrointestinal and gynaecological evaluation in premenopausal women with iron deficiency anaemia. Aliment Pharmacol Ther. 2008;28:422–430. - PubMed

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