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. 2009 Jun;15(6):966-8.
doi: 10.3201/eid1506.081357.

Oseltamivir- and amantadine-resistant influenza viruses A (H1N1)

Peter K C Cheng  1 , Tommy W C Leung, Eric C M Ho, Peter C K Leung, Anita Y Y Ng, Mary Y Y Lai, Wilina W L Lim
Affiliations

Oseltamivir- and amantadine-resistant influenza viruses A (H1N1)

Peter K C Cheng et al. Emerg Infect Dis. 2009 Jun.

Abstract

Surveillance of amantadine and oseltamivir resistance among influenza viruses was begun in Hong Kong in 2006. In 2008, while both A/Brisbane/59/2007-like and A/Hong Kong/2652/2006-like viruses (H1N1) were cocirculating, we detected amantadine and oseltamivir resistance among A/Hong Kong/2652/2006-like viruses (H1N1), caused by genetic reassortment or spontaneous mutation.

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Figures

Figure
Figure
Phylogenetic analysis of the hemagglutinin gene (A), neuraminidase gene (B), and matrix gene (C) of influenza virus (H1N1). The 3 clade 2C viruses with double resistance are indicated by circles, the 3 clade 2B viruses with amantadine resistance are indicated by triangles, and A/Brisbane/59/2007 and A/Hong Kong/2652/2006 are indicated by squares. Scale bars indicate 0.5% difference in nucleotide sequence.
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