[Pharmacological hypertension therapy]

Abstract

Drug therapy in uncomplicated hypertension can be initiated with either ACE-inhibitors, angiotensin II receptor antagonists, calcium channel blockers or thiazides. In younger patients, the first three classes are preferable. Beta-blockers are first-line drugs for hypertension in patients with cardiac comorbidity. Initial combination therapy is indicated in high-risk patients where blood pressure reduction of > 20/10 mmHg is desired. Resistant hypertension generally calls for an increment in diuretic dosage and/or addition of a potassium-sparing diuretic.