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Review
. 2009 Aug;21(4):603-12.
doi: 10.1016/j.ceb.2009.05.001. Epub 2009 Jun 11.

Nuclear pore complex biogenesis

Javier Fernandez-Martinez  1 , Michael P Rout
Affiliations
Review

Nuclear pore complex biogenesis

Javier Fernandez-Martinez et al. Curr Opin Cell Biol. 2009 Aug.

Abstract

Nuclear pore complexes (NPCs) are the sole mediators of transport between the nucleus and the cytoplasm. NPCs have a life cycle: they assemble, disassemble, turnover, and age. The molecular mechanisms governing these different vital steps are beginning to emerge, suggesting key roles for the core structural scaffold of the NPC and auxiliary factors in the assembly of this large macromolecular complex, and connections between NPC maintenance, NPC turnover, and aging of the cell.

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Figures

Figure 1
Figure 1
Structure of the NPC. Major features of the interphase NPC and its surrounding NE are indicated; see main text for details (map based on [5•]).
Figure 2
Figure 2
Schematic Illustrating the Different Types of Mitosis. During mitosis, the mitotic spindle (purple) forms while the NE (orange) and NPCs (blue) are retained to differing degrees, resulting in the nucleoplasm (green) being retained only in the closed form of mitosis. To the right are shown which major features of the NPC are still intact, and which are dispersed.
Figure 3
Figure 3
Proposed Path of Interphase NPC Assembly; see main text for details.
See this image and copyright information in PMC

References

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    1. Alber F, Dokudovskaya S, Veenhoff LM, Zhang W, Kipper J, Devos D, Suprapto A, Karni-Schmidt O, Williams R, Chait BT, et al. The molecular architecture of the nuclear pore complex. Nature. 2007;450:695–701.Using diverse sources of proteomic and structural experimental data, for the first time the authors were able to calculate a structure for the whole yeast NPC where the position of each nucleoporin within the overall architecture of the NPC is resolved. Major structural features of the NPC and their nucleoporin composition are described, revealing a close evolutionary relationship between the structures of membrane coating complexes and the NPC.

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