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Comment
. 2009 Jun 12;137(6):988-90.
doi: 10.1016/j.cell.2009.05.024.

Jagged gives endothelial tip cells an edge

Steven Suchting  1 , Anne Eichmann
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Free article
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Jagged gives endothelial tip cells an edge

Steven Suchting et al. Cell. .
Free article

Abstract

Sprouting blood vessels have tip cells that lead and stalk cells that follow. Benedito et al. (2009) now show that competition between endothelial cells for the tip position is regulated by glycosylation of Notch receptors and by the opposing actions of the Notch ligands Jagged1 and Delta-like 4.

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