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Comment
. 2009 Jun 12;137(6):994-6.
doi: 10.1016/j.cell.2009.05.041.

Prion topology and toxicity

Adriano Aguzzi  1 , Andrew D Steele
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Free article
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Prion topology and toxicity

Adriano Aguzzi et al. Cell. .
Free article

Abstract

Inactivation of mahogunin, an E3 ubiquitin ligase, causes a spongiform encephalopathy resembling prion disease. Chakrabarti and Hegde (2009) now report that prion proteins with aberrant topologies inactivate mahogunin, providing a plausible explanation for certain aspects of prion pathology.

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