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. 2009 Oct;80(7):427-31.
doi: 10.1016/j.fitote.2009.06.002. Epub 2009 Jun 11.

Bioactive constituents from the stems of Dalbergia parviflora

Uraiwan Songsiang  1 , Suchana Wanich, Siripit Pitchuanchom, Siwames Netsopa, Komphet Uanporn, Chavi Yenjai
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Bioactive constituents from the stems of Dalbergia parviflora

Uraiwan Songsiang et al. Fitoterapia. 2009 Oct.

Abstract

From the stems of Dalbergia parviflora, three known flavonoids, six known isoflavonoids, a new isoflavone, dalparvone (2) and a new cinnamyl derivative, dalparvinene (6) were isolated and characterized. Isoflavan 3 exhibited strong cytotoxicity against KB and NCI-H187 cell lines with IC(50) values of 0.53 and 2.04 microg/ml, respectively. Compound 6 demonstrated strong cytotoxicity against NCI-H187 with an IC(50) value of 1.46 microg/ml. Compounds 4 and 6 possessed moderate cytotoxicity against KB cells with IC(50) values of 6.78 and 9.89 microg/ml, respectively. In addition, 2 exhibited moderate antiplasmodial activity with an IC(50) value of 8.19 microg/ml.

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