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. 2009 Sep;46(9):714-20.
doi: 10.1016/j.fgb.2009.06.003. Epub 2009 Jun 13.

Rep1p negatively regulating MDR1 efflux pump involved in drug resistance in Candida albicans

Chia-Geun Chen  1 , Yun-Liang Yang, Kuo-Yun Tseng, Hsin-I Shih, Ci-Hong Liou, Chih-Chao Lin, Hsiu-Jung Lo
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Rep1p negatively regulating MDR1 efflux pump involved in drug resistance in Candida albicans

Chia-Geun Chen et al. Fungal Genet Biol. 2009 Sep.

Abstract

Overexpression of MDR1 efflux pump is a major mechanism contributing to drug resistance in Candida albicans, the most common human fungal pathogen. To elucidate the regulatory pathway of drug resistance, we have identified a negative regulator of MDR1 and named it Regulator of Efflux Pump 1 (REP1). Overexpression of REP1 in Saccharomyces cerevisiae increased susceptibility to fluconazole. Furthermore, null mutations on REP1 decreased the susceptibility to antifungal drugs in C. albicans resulting from increased expression of MDR1 mRNA. Hence, Rep1p is involved in drug resistance by negatively regulating MDR1 in C. albicans.

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