Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1991 Sep;35(9):1923-4.
doi: 10.1128/AAC.35.9.1923.

Effects of chlorpromazine on the cell envelope proteins of Escherichia coli

L Amaral  1 , V Lorian
Affiliations

Effects of chlorpromazine on the cell envelope proteins of Escherichia coli

L Amaral et al. Antimicrob Agents Chemother. 1991 Sep.

Abstract

Chlorpromazine (CPZ), at a concentration of 60 micrograms/ml of medium completely inhibited the replication of Escherichia coli. At concentrations below this MIC, CPZ caused transient induction of filamentation, such that by the end of 5 h, all of the cells were filaments, and by the end of 24 h, only rod-shaped E. coli were present. The reversion to normal morphology in the presence of CPZ was not due to either the degradation of CPZ or the selection of CPZ-resistant mutants. The electrophoretic pattern of proteins extracted from isolated cell envelopes of CPZ-induced filaments as well as from E. coli that reverted to normal morphology was distinctly different from that of the controls.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Ann Inst Pasteur (Paris). 1961 Dec;101:876-86 - PubMed
    1. Presse Med. 1959 Jan 31;67(6):212 - PubMed
    1. Dan Med Bull. 1989 Apr;36(2):178-85 - PubMed
    1. Theriogenology. 1981 Aug;16(2):179-84 - PubMed
    1. J Bacteriol. 1986 Aug;167(2):492-5 - PubMed

MeSH terms

LinkOut - more resources