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Review
. 2009 Apr-Jun;11(2):59-70.

The challenge of HIV-1 antiretroviral resistance in Africa in the era of HAART

Hakim Sendagire  1 , Philippa J Easterbrook, Immaculate Nankya, Eric Arts, David Thomas, Steven J Reynolds
Affiliations
Review

The challenge of HIV-1 antiretroviral resistance in Africa in the era of HAART

Hakim Sendagire et al. AIDS Rev. 2009 Apr-Jun.

Abstract

Antiretroviral therapy programs in Africa are currently providing treatment for almost two million people. The long-term success of large scale antiretroviral therapy programs in sub-Saharan Africa remains uncertain because of the limited information currently available on rates of virologic failure and selection for drug-resistant variants in the different HIV subtypes. This article provides a comprehensive review of the published literature on the prevalence of primary and secondary HIV drug resistance with different subtypes and in various settings across sub-Saharan Africa.

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Figures

Figure 1
Figure 1. Map of the world showing the various HIV subtypes prevalent in different regions
Image reproduced from AIDS Rev. 2003;5:205–13.
See this image and copyright information in PMC

References

    1. UNAIDS. Report on the global AIDS epidemic: Global facts and figures. 2008 http://data.unaids.org/pub/GlobalReport/2008/20080715_fs_global_en.pdf.
    1. WHO. Antiretroviral drugs for the treatment of HIV infection in adult and adolescents in resource limited settings: Recommendations for a Public Health Approach (2005–6 Revision) Web 2005.
    1. Barth R, Wensing A, Tempelman H, Moraba R, Schuurman R, Hoepelman A. Rapid accumulation of nonnucleoside reverse transcriptase inhibitor-associated resistance: evidence of transmitted resistance in rural South Africa. AIDS. 2008;22:2210–12. - PubMed
    1. Petersen M, van der Laan M, Napravnik S, Eron J, Moore R, Deeks S. Long-term consequences of the delay between virologic failure of highly active antiretroviral therapy and regimen modification. AIDS. 2008;22:2097–106. - PMC - PubMed
    1. Harries A, Nyangulu D, Hargreaves N, Kaluwa O, Salaniponi F. Preventing antiretroviral anarchy in sub-Saharan Africa. Lancet. 2001;358:410–14. - PubMed

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