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Comment
. 2009 Jul;2(4):375-6.
doi: 10.1038/mi.2009.21.

Role of Th17 cells in the immunopathogenesis of dry eye disease

S K Chauhan, R Dana
Comment

Role of Th17 cells in the immunopathogenesis of dry eye disease

S K Chauhan et al. Mucosal Immunol. 2009 Jul.
No abstract available

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Figures

Figure 1
Figure 1. Immunopathogenesis of dry eye disease
Ocular surface inflammation in DE is sustained by ongoing activation and infiltration of pathogenic immune cells, primarily CD4+ T cells in the conjunctiva and CD11b+ monocytic cells in the cornea–. [I.] Dessicating stress induces secretion of inflammatory cytokines especially IL-1, TNFα and IL-6 by ocular surface tissues which facilitate activation and migration of resident antigen presenting cells (APC) toward the regional draining lymph nodes (LN). [II.] In the LN, these APCs stimulate cognate naïve T cells (Th0) leading to the expansion of IL-17 secreting Th17 cells and IFN-γ secreting Th1 cells. IL-17 in turn antagonizes the Treg function by facilitating further expansion of Th17 cells which may compete with Tregs for TGF-β available in the milieu. [III.] Once these effectors are generated in the LN, they migrate to the ocular surface and secret effector cytokines. Interaction of IL-17 with its receptors on ocular surface leads to epithelial damage via increase secretion of matrix metalloproteinases (MMP) and inflammatory cytokines. In addition to apoptosis and metaplasia of ocular surface epithelia, IFN-γ causes upregulation of chemokine ligands/receptor and adhesion molecules (CAM) which facilitate increased ingress of immune cells to the ocular surface tissues.
See this image and copyright information in PMC

Comment on

  • IL-17 disrupts corneal barrier following desiccating stress.
    De Paiva CS, Chotikavanich S, Pangelinan SB, Pitcher JD 3rd, Fang B, Zheng X, Ma P, Farley WJ, Siemasko KF, Niederkorn JY, Stern ME, Li DQ, Pflugfelder SC. De Paiva CS, et al. Mucosal Immunol. 2009 May;2(3):243-53. doi: 10.1038/mi.2009.5. Epub 2009 Feb 25. Mucosal Immunol. 2009. PMID: 19242409 Free PMC article.

References

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    1. Pflugfelder SC, de Paiva CS, Li DQ, Stern ME. Epithelial-immune cell interaction in dry eye. Cornea. 2008;27 Suppl 1:S9–S11. - PMC - PubMed
    1. Report of the International Dry Eye WorkShop. Ocul. Surf. 2007;5:179–193. No authors listed. - PubMed
    1. Barabino S, Dana MR. Dry eye syndromes. Chem. Immunol. Allergy. 2007;92:176–184. - PubMed
    1. Chauhan SK, El Annan J, Ecoiffier T, Goyal S, Zhang Q, Saban DR, Dana R. Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression. J. Immunol. 2009;182:1247–1252. - PMC - PubMed

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