Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009 Sep;31(3):421-35.
doi: 10.1007/s00281-009-0170-7. Epub 2009 Jun 17.

Autoimmune hepatitis

Diego Vergani  1 , Maria Serena Longhi, Dimitrios P Bogdanos, Yun Ma, Giorgina Mieli-Vergani
Affiliations
Review

Autoimmune hepatitis

Diego Vergani et al. Semin Immunopathol. 2009 Sep.

Abstract

Autoimmune hepatitis (AIH) is an inflammatory liver disease affecting mainly females and characterised histologically by interface hepatitis, biochemically by elevated transaminase levels and serologically by the presence of autoantibodies and increased levels of immunoglobulin G. AIH responds to immunosuppressive treatment, which should be instituted as soon as diagnosis is made. Seropositivity for smooth muscle and/or anti-nuclear antibody defines type 1 AIH, while positivity for liver kidney microsomal type 1 antibody defines type 2 AIH. The aetiology of AIH is unknown, though both genetic and environmental factors are involved in its expression. Immune reactions against host liver antigens are believed to be the major mechanism of liver damage.

PubMed Disclaimer

References

    1. Hepatology. 2008 Feb;47(2):581-91 - PubMed
    1. Hepatology. 2001 Mar;33(3):544-53 - PubMed
    1. Lancet. 2000 Apr 29;355(9214):1510-5 - PubMed
    1. Gastroenterology. 2006 Mar;130(3):868-82 - PubMed
    1. Lancet. 1990 Dec 22-29;336(8730):1527-30 - PubMed

MeSH terms

LinkOut - more resources