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. 2009 Jun;80(4):230-2.
doi: 10.1016/j.fitote.2009.02.002. Epub 2009 Feb 12.

Preliminary analysis of the antinociceptive activity of zerumbone

M R Sulaiman  1 , E K Perimal, Z A Zakaria, F Mokhtar, M N Akhtar, N H Lajis, D A Israf
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Preliminary analysis of the antinociceptive activity of zerumbone

M R Sulaiman et al. Fitoterapia. 2009 Jun.

Abstract

We have investigated the antinociceptive activity of zerumbone (1), a natural cyclic sesquiterpene isolated from Zingiber zerumbet Smith, in acetic acid-induced abdominal writhing test and hot plate test in mice. 1 given by intraperitoneal route produced significant dose-dependent antinociceptive effect in all the test models used. In addition, the antinociceptive effect of 1 in the hot plate test was reversed by the non-selective opioid receptor antagonist naloxone, suggesting that the opioid system is involved in its analgesic mechanism of action.

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