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. 2009 Jul;16(Pt 4):587-90.
doi: 10.1107/S0909049509012485. Epub 2009 May 12.

First trial of spatial and temporal fractionations of the delivered dose using synchrotron microbeam radiation therapy

Raphaël Serduc  1 , Elke Bräuer-Krisch, Audrey Bouchet, Luc Renaud, Thierry Brochard, Alberto Bravin, Jean Albert Laissue, Géraldine Le Duc
Affiliations

First trial of spatial and temporal fractionations of the delivered dose using synchrotron microbeam radiation therapy

Raphaël Serduc et al. J Synchrotron Radiat. 2009 Jul.

Abstract

The technical feasibility of temporal and spatial fractionations of the radiation dose has been evaluated using synchrotron microbeam radiation therapy for brain tumors in rats. A significant increase in lifespan (216%, p < 0.0001) resulted when three fractions of microbeam irradiation were applied to the tumor through three different ports, orthogonal to each other, at 24 h intervals. However, there were no long-term survivors, and immunohistological studies revealed that 9 L tumors were not entirely ablated.

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