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. 2009 Jun;26(6):617-21.
doi: 10.1111/j.1464-5491.2009.02731.x.

Quality of life after islet transplantation: data from the GRAGIL 1 and 2 trials

P Y Benhamou  1 , L Milliat-Guittard, A Wojtusciszyn, L Kessler, C Toso, R Baertschiger, I Debaty, L Badet, A Penfornis, C Thivolet, E Renard, F Bayle, P Morel, E Morelon, C Colin, T Berney; GRAGIL group
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Quality of life after islet transplantation: data from the GRAGIL 1 and 2 trials

P Y Benhamou et al. Diabet Med. 2009 Jun.

Abstract

Background: Rigorous assessment of health-related quality of life (HRQL) is mandatory to establish the benefits of islet transplantation.

Methods: The 36-Item Short Form Health Survey (SF-36) and the Diabetes Quality of Life (DQOL) scales were completed by patients included in an Islet Transplantation Alone (ITA) trial (n = 10) and an Islet After Kidney (IAK) trial (n = 10).

Results: The two populations differed by HRQL scores at baseline, with poorer scores in ITA patients. SF-36 scores for physical limitations, bodily pain, general health perception, social functioning, and health transition improved significantly in ITA patients 6 and 12 months post transplantation. The DQOL global score was significantly improved at 6 months and remained so at 12 months, because of a significant improvement in the dimensions of satisfaction and impact of diabetes. No improvement was observed in the IAK patients.

Conclusion: HRQL assessment may help in the selection of candidates with brittle diabetes for islet transplantation.

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