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Review
. 2009 Sep;13(9A):2822-33.
doi: 10.1111/j.1582-4934.2009.00810.x. Epub 2009 Jun 16.

Immune cells and angiogenesis

Domenico Ribatti  1 , Enrico Crivellato
Affiliations
Review

Immune cells and angiogenesis

Domenico Ribatti et al. J Cell Mol Med. 2009 Sep.

Abstract

Both innate and adaptive immune cells are involved in the mechanisms of endothelial cell proliferation, migration and activation, through the production and release of a large spectrum of pro-angiogenic mediators. These may create the specific microenvironment that favours an increased rate of tissue vascularization. In this review, we will focus on the immune cell component of the angiogenic process in inflammation and tumour growth. As angiogenesis is the result of a net balance between the activities exerted by positive and negative regulators, we will also provide information on some antiangiogenic properties of immune cells that may be utilized for a potential pharmacological use as antiangiogenic agents in inflammation as well as in cancer.

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Figures

Figure 1
Figure 1
Interplay between angiogenic and anti-angiogenic molecules secreted by NK cells, mast cells, basophils and eosinophils.
Figure 2
Figure 2
Interplay between angiogenic and anti-angiogenic molecules secreted by neutrophils, monocytes-macrophages and dendritic cells.
See this image and copyright information in PMC

References

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Publication types