Review
doi: 10.1016/0955-0674(91)90153-p.
The role of p53 in the normal control of cell proliferation
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- PMID: 1953903
- DOI: 10.1016/0955-0674(91)90153-p
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Review
The role of p53 in the normal control of cell proliferation
Curr Opin Cell Biol.
1991 Apr.
Erratum in
- Curr Opin Cell Biol 1991 Jun;3(3):following 574
Abstract
The regulation of cell proliferation involves p53. A mutant allele of p53, p53-Val135, has been found to be temperature-sensitive for function with separable suppressor and promoter effects on cell proliferation. These opposing suppressor and promoter functions of p53 correlate with two alternative, temperature-sensitive conformations of the p53-Val135 polypeptide.
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