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Randomized Controlled Trial
. 2009 Sep;32(9):1597-9.
doi: 10.2337/dc08-2322. Epub 2009 Jun 18.

Effects of a diet higher in carbohydrate/lower in fat versus lower in carbohydrate/higher in monounsaturated fat on postmeal triglyceride concentrations and other cardiovascular risk factors in type 1 diabetes

Irene Strychar  1 , Jeffrey S Cohn, Geneviève Renier, Michèle Rivard, Nahla Aris-Jilwan, Hugues Beauregard, Sara Meltzer, André Bélanger, Richard Dumas, Alain Ishac, Farouk Radwan, Jean-François Yale
Affiliations
Randomized Controlled Trial

Effects of a diet higher in carbohydrate/lower in fat versus lower in carbohydrate/higher in monounsaturated fat on postmeal triglyceride concentrations and other cardiovascular risk factors in type 1 diabetes

Irene Strychar et al. Diabetes Care. 2009 Sep.

Abstract

Objective: To compare the effects of a eucaloric diet higher in carbohydrate/lower in fat versus lower in carbohydrate/higher in monounsaturated fat on postmeal triglyceride (TG) concentrations and other cardiovascular disease risk factors in nonobese subjects with type 1 diabetes and in good glycemic control.

Research design and methods: In a parallel group design study, 30 subjects were randomly assigned and completed one of the two eucaloric diets. Assessments included: BMI, blood pressure, A1C, plasma lipids, and markers of oxidation, thrombosis, and inflammation. At 6 months, subjects were hospitalized for 24 h to measure plasma TG excursions.

Results: There were no significant differences between groups other than decreased plasminogen activator inhibitor 1 (PAI-1) levels and weight gain in the lower-carbohydrate/higher-monounsaturated fat group. During the 24-h testing, the lower-carbohydrate/higher-monounsaturated fat group had a lower plasma TG profile.

Conclusions: A diet lower in carbohydrate/higher in monounsaturated fat could offer an appropriate choice for nonobese type 1 diabetic individuals with good metabolic and weight control.

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References

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