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Review
. 2009 Jun;23(6):441-5.
doi: 10.1155/2009/591317.

Abnormal hematological indices in cirrhosis

A A Qamar  1 , N D Grace
Affiliations
Review

Abnormal hematological indices in cirrhosis

A A Qamar et al. Can J Gastroenterol. 2009 Jun.

Abstract
in English, French

Abnormalities in hematological indices are frequently encountered in cirrhosis. Multiple causes contribute to the occurrence of hematological abnormalities. Recent studies suggest that the presence of hematological cytopenias is associated with a poor prognosis in cirrhosis. The present article reviews the pathogenesis, incidence, prevalence, clinical significance and treatment of abnormal hematological indices in cirrhosis.

On observe souvent des anomalies des indices hématologiques dans la cirrhose. Plusieurs causes contribuent à ces anomalies hématologiques. De récentes études donnent à penser que la présence de cytopénies hématologiques soit associée à un pronostic sombre dans la cirrhose. Le présent article passe en revue la pathogenèse, l’incidence, la prévalence, la portée clinique et le traitement des indices hématologiques anormaux dans la cirrhose.

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Figures

Figure 1
Figure 1
The prevalence of abnormal hematological indices in cirrhosis patients with clinically significant (hepatic venous pressure gradient ≥ 10 mmHg) compared with clinically insignificant (hepatic venous prssure gradient <10 mmHg) portal hypertension (n=213). Anemia defined as a hemoglobin level of less than 135 g/L for men and less than 115 g/L for women. Leukopenia defined as a white blood cell count of less than 400×109/L. Thrombocytopenia defined as a platelet count of less than 150×109/L
Figure 2
Figure 2
Relationship between the presence of small varices (SV), large varices (LV), variceal hemorrhage (VH) and platelet count (PLT) ranges at the time of occurrence of varices or VH. Adapted from reference
See this image and copyright information in PMC

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