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. 2009 Oct;256(10):1719-23.
doi: 10.1007/s00415-009-5190-7. Epub 2009 Jun 21.

AChR deficiency due to epsilon-subunit mutations: two common mutations in the Netherlands

Catharina G Faber  1 , Peter C Molenaar, Johannes S H Vles, Domenic M Bonifati, Jan J G M Verschuuren, Pieter A van Doorn, Jan B M Kuks, John H J Wokke, David Beeson, Marc De Baets
Affiliations

AChR deficiency due to epsilon-subunit mutations: two common mutations in the Netherlands

Catharina G Faber et al. J Neurol. 2009 Oct.

Abstract

Congenital myasthenic syndromes are a clinically and genetically heterogeneous group of hereditary disorders affecting neuromuscular transmission. We have identified mutations within the acetylcholine receptor (AChR) epsilon-subunit gene underlying congenital myasthenic syndromes in nine patients (seven kinships) of Dutch origin. Previously reported mutations epsilon1369delG and epsilonR311Q were found to be common; epsilon1369delG was present on at least one allele in seven of the nine patients, and epsilonR311Q in six. Phenotypes ranged from relatively mild ptosis and external ophthalmoplegia to generalized myasthenia. The common occurrence of epsilonR311Q and epsilon1369delG suggests a possible founder for each of these mutations originating in North Western Europe, possibly in Holland. Knowledge of the ethnic or geographic origin within Europe of AChR deficiency patients can help in targeting genetic screening and it may be possible to provide a rapid genetic diagnosis for patients of Dutch origin by screening first for epsilonR311Q and epsilon1369delG.

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Figures

Fig. 1
Fig. 1
a Restriction endonuclease digests of PCR amplicons of the AChR ε-subunit gene exons 9 and 12 amplified from genomic DNA. Affected individuals (shaded) in the kinship (patients 1 and 2) carry two mutant alleles, whereas members carrying one (half-shaded) are unaffected. b Example of SNP haplotypes within the 3′ untranslated region of CHRNE showing the kinship containing patients 1 and 2, derived by DNA sequencing of genomic DNA from family members. Haplotype T A T G is seen to associate with the allele harbouring e1369delG and haplotype G A G C with the allele harbouring R311Q
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