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Review
. 2009 Jun 22;169(12):1113-21; discussion 1121-2.
doi: 10.1001/archinternmed.2009.136.

Cost-effectiveness of total knee arthroplasty in the United States: patient risk and hospital volume

Elena Losina  1 , Rochelle P Walensky, Courtenay L Kessler, Parastu S Emrani, William M Reichmann, Elizabeth A Wright, Holly L Holt, Daniel H Solomon, Edward Yelin, A David Paltiel, Jeffrey N Katz
Affiliations
Review

Cost-effectiveness of total knee arthroplasty in the United States: patient risk and hospital volume

Elena Losina et al. Arch Intern Med. .

Abstract

Background: Total knee arthroplasty (TKA) relieves pain and improves quality of life for persons with advanced knee osteoarthritis. However, to our knowledge, the cost-effectiveness of TKA and the influences of hospital volume and patient risk on TKA cost-effectiveness have not been investigated in the United States.

Methods: We developed a Markov, state-transition, computer simulation model and populated it with Medicare claims data and cost and outcomes data from national and multinational sources. We projected lifetime costs and quality-adjusted life expectancy (QALE) for different risk populations and varied TKA intervention and hospital volume. Cost-effectiveness of TKA was estimated across all patient risk and hospital volume permutations. Finally, we conducted sensitivity analyses to determine various parameters' influences on cost-effectiveness.

Results: Overall, TKA increased QALE from 6.822 to 7.957 quality-adjusted life years (QALYs). Lifetime costs rose from $37,100 (no TKA) to $57 900 after TKA, resulting in an incremental cost-effectiveness ratio of $18,300 per QALY. For high-risk patients, TKA increased QALE from 5.713 to 6.594 QALY, yielding a cost-effectiveness ratio of $28,100 per QALY. At all risk levels, TKA was more costly and less effective in low-volume centers than in high-volume centers. Results were insensitive to variations of key input parameters within policy-relevant, clinically plausible ranges. The greatest variations were seen for the quality of life gain after TKA and the cost of TKA.

Conclusions: Total knee arthroplasty appears to be cost-effective in the US Medicare-aged population, as currently practiced across all risk groups. Policy decisions should be made on the basis of available local options for TKA. However, when a high-volume hospital is available, TKAs performed in a high-volume hospital confer even greater value per dollar spent than TKAs performed in low-volume centers.

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Figures

Figure 1
Figure 1
Total knee arthroplasty (TKA) model structure not including the tenth and absorbing state, death. OA indicates osteoarthritis; straight arrows, transition from one state to another; curved arrows, no transition to a new state. A detailed explanation of each state and the movement between states is available in the “Methods” section.
Figure 2
Figure 2
Sensitivity analysis of potentially important model parameters. The bars represent ranges of incremental cost-effectiveness ratio values when the value of indicated parameter is changed over the range shown in parentheses. QOL indicates quality of life; TKA, total knee arthroplasty; QALY, quality-adjusted life years. Varying the proportion of persons who lacked substantial functional improvement after revision (reduced by 50% and increased by 100%) did not have a significant impact on incremental cost-effectiveness ratios.
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