Chromosome segregation: monopolin goes spindle
- PMID: 19549493
- DOI: 10.1016/j.cub.2009.05.006
Chromosome segregation: monopolin goes spindle
Abstract
At anaphase onset the mitotic spindle undergoes dramatic changes in order to segregate sister chromatids. Surprisingly, the monopolin complex, best known for its role at kinetochores in meiosis, is now shown to localize to, and stabilize, the mitotic anaphase spindle.
Comment on
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Phosphorylation state defines discrete roles for monopolin in chromosome attachment and spindle elongation.Curr Biol. 2009 Jun 23;19(12):985-95. doi: 10.1016/j.cub.2009.05.042. Epub 2009 Jun 11. Curr Biol. 2009. PMID: 19523829 Free PMC article.
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