doi: 10.1016/j.chembiol.2009.06.002.
Oxygenase catalyzed 5-methylcytosine hydroxylation
Affiliations
- PMID: 19549596
- DOI: 10.1016/j.chembiol.2009.06.002
Item in Clipboard
Oxygenase catalyzed 5-methylcytosine hydroxylation
Chem Biol.
.
Abstract
Recent reports identify the oxygenase catalyzed production of 5-hydroxymethylcytosine as a modification to mammalian DNA (Kriaucionis and Heintz, 2009; Tahiliani et al., 2009). This discovery has potential far-reaching implications for epigenetic regulation and will stimulate efforts to identify new nucleic acid modifications.
Similar articles
-
TET1 is a DNA-binding protein that modulates DNA methylation and gene transcription via hydroxylation of 5-methylcytosine.Cell Res. 2010 Dec;20(12):1390-3. doi: 10.1038/cr.2010.156. Epub 2010 Nov 16. Cell Res. 2010. PMID: 21079648 No abstract available.
-
Biochemical characterization of a Naegleria TET-like oxygenase and its application in single molecule sequencing of 5-methylcytosine.Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4316-21. doi: 10.1073/pnas.1417939112. Epub 2015 Mar 23. Proc Natl Acad Sci U S A. 2015. PMID: 25831492 Free PMC article.
-
Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain.Cell. 2011 Apr 29;145(3):423-34. doi: 10.1016/j.cell.2011.03.022. Epub 2011 Apr 14. Cell. 2011. PMID: 21496894 Free PMC article.
-
TET enzymatic oxidation of 5-methylcytosine, 5-hydroxymethylcytosine and 5-formylcytosine.Mutat Res Genet Toxicol Environ Mutagen. 2014 Apr;764-765:18-35. doi: 10.1016/j.mrgentox.2013.09.001. Epub 2013 Sep 14. Mutat Res Genet Toxicol Environ Mutagen. 2014. PMID: 24045206 Review.
-
Genomic distribution and possible functions of DNA hydroxymethylation in the brain.Genomics. 2014 Nov;104(5):341-6. doi: 10.1016/j.ygeno.2014.08.020. Epub 2014 Sep 7. Genomics. 2014. PMID: 25205307 Review.
Cited by
-
Phosphorylation of TET proteins is regulated via O-GlcNAcylation by the O-linked N-acetylglucosamine transferase (OGT).J Biol Chem. 2015 Feb 20;290(8):4801-4812. doi: 10.1074/jbc.M114.605881. Epub 2015 Jan 7. J Biol Chem. 2015. PMID: 25568311 Free PMC article.
-
TET2 Inhibits Differentiation of Embryonic Stem Cells but Does Not Overcome Methylation-Induced Gene Silencing.Bone Marrow Res. 2014;2014:986571. doi: 10.1155/2014/986571. Epub 2014 Aug 25. Bone Marrow Res. 2014. PMID: 25276435 Free PMC article.
-
Epigenetic regulation of stem cells differentiating along the neural lineage.Curr Opin Neurobiol. 2012 Oct;22(5):762-7. doi: 10.1016/j.conb.2012.07.001. Epub 2012 Jul 24. Curr Opin Neurobiol. 2012. PMID: 22835699 Free PMC article. Review.
-
Sensitive enzymatic quantification of 5-hydroxymethylcytosine in genomic DNA.Nucleic Acids Res. 2010 Oct;38(19):e181. doi: 10.1093/nar/gkq684. Epub 2010 Aug 4. Nucleic Acids Res. 2010. PMID: 20685817 Free PMC article.
-
2'-Deoxy-5-(hydroxymethyl)cytidine: estimation in human cancer cells with a simple chemosensor.RSC Adv. 2018 Nov 29;8(70):39893-39896. doi: 10.1039/c8ra08391f. eCollection 2018 Nov 28. RSC Adv. 2018. PMID: 35558208 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
