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. 2009 Jun 26;16(6):580-3.
doi: 10.1016/j.chembiol.2009.06.002.

Oxygenase catalyzed 5-methylcytosine hydroxylation

Christoph Loenarz  1 , Christopher J Schofield
Affiliations

Oxygenase catalyzed 5-methylcytosine hydroxylation

Christoph Loenarz et al. Chem Biol. .

Abstract

Recent reports identify the oxygenase catalyzed production of 5-hydroxymethylcytosine as a modification to mammalian DNA (Kriaucionis and Heintz, 2009; Tahiliani et al., 2009). This discovery has potential far-reaching implications for epigenetic regulation and will stimulate efforts to identify new nucleic acid modifications.

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