Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Sep;32(9):1647-8.
doi: 10.2337/dc09-0553. Epub 2009 Jun 23.

Ketoacidosis at diabetes onset is still frequent in children and adolescents: a multicenter analysis of 14,664 patients from 106 institutions

Andreas Neu  1 , Sabine E Hofer, Beate Karges, Rudolf Oeverink, Joachim Rosenbauer, Reinhard W Holl; DPV Initiative and the German BMBF Competency Network for Diabetes Mellitus
Affiliations

Ketoacidosis at diabetes onset is still frequent in children and adolescents: a multicenter analysis of 14,664 patients from 106 institutions

Andreas Neu et al. Diabetes Care. 2009 Sep.

Abstract

Objective: We aimed at analyzing the frequency, clinical characteristics, and trends associated with the occurrence of diabetic ketoacidosis (DKA) at the onset of type 1 diabetes on the basis of long-term follow-up data.

Research design and methods: A total of 106 pediatric diabetes centers in Germany and Austria participated in this study. Data from 14,664 patients with type 1 diabetes collected between 1995 and 2007 were suitable for evaluation. DKA was defined and classified according to the International Society for Pediatric and Adolescent Diabetes consensus guidelines.

Results: DKA was observed in 21.1% of patients. The frequency of DKA, including the severe form, remained unchanged throughout the 13-year observation period. The frequency of DKA was particularly striking among children <5 years of age (26.5%).

Conclusions: Ketoacidosis occurring at diabetes onset continues to be a difficult problem. Our data show no significant change in the frequency and magnitude of DKA over the last 13 years.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Frequency of DKA according to years. ♦, pH <7.3; ■, pH <7.2; ▲, pH <7.
See this image and copyright information in PMC

References

    1. Kintzel K, Holl R, Haberland H, Grabert M, Dost A. The diabetic ketoacidosis (DKA) with disease beginning in childhood and adolescence in the Federal Republic. Diab Stoffw 2003; 12: 8– 12 [ in German]
    1. Wolfsdorf J, Craig ME, Daneman D, Dunger D, Edge J, Lee WRW, Rosenbloom A, Sperling MA, Hanas R. ISPAD clinical practice consensus guidelines 2006–2007: diabetic ketoacidosis. Pediatr Diabetes 2007; 8: 28– 43 - PubMed
    1. Rewers A, Klingensmith G, Davis C, Petitti DB, Pihoker C, Rodriguez B, Schwartz ID, Imperatore G, Williams D, Dolan LM, Dabelea D. Presence of diabetic ketoacidosis at diagnosis of diabetes mellitus in youth: the Search for Diabetes in Youth Study. Pediatrics 2008; 121: e1258– e1266 - PubMed
    1. Ehehalt S, Blumenstock G, Willasch AM, Hub R, Ranke MB, Neu A; DIARY-study Group Baden-Württemberg. Continuous rise in incidence of childhood type 1 diabetes in Germany. Diabet Med 2008; 25: 755– 757 - PubMed
    1. Neu A, Ehehalt S, Feldhahn LM, Kehrer M, Willasch AM, Hub R, Ranke MB; for the DIARY Group Baden-Wüerttemberg: Diabetes incidence in children and adolescents in Germany: 20 years diabetes incidence registry Baden-Württemberg. Diabetology and Metabolism 2008; 3: 309– 313 [in German]

Publication types