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. 2009 Oct;28(10):1227-36.
doi: 10.1007/s10096-009-0772-y. Epub 2009 Jun 24.

The association of vacA genotypes and Helicobacter pylori-related gastroduodenal diseases in the Middle East

M Sugimoto  1 , M R Zali, Y Yamaoka
Affiliations

The association of vacA genotypes and Helicobacter pylori-related gastroduodenal diseases in the Middle East

M Sugimoto et al. Eur J Clin Microbiol Infect Dis. 2009 Oct.

Abstract

The variations in the three regions of the Helicobacter pylori vacA gene, the signal (s1 and s2), intermediate (i1 and i2) and middle regions (m1 and m2), are known to cause the differences in vacuolating activities. However, it was unclear whether these vacA genotypes are associated with the development of gastric cancer and peptic ulcer in the Middle East. The aim was to identify the prevalence of vacA genotypes in the Middle East and the association with gastroduodenal diseases. We investigated the relationship of vacA genotypes to H. pylori-related disease development by meta-analysis using previous reports of 1,646 patients from the Middle East. The frequency of the vacA s1, m1 and i1 genotypes in the Middle Eastern strains was 71.5% (1,007/1,409), 32.8% (427/1,300) and 40.7% (59/145), respectively. Importantly, the frequency of vacA s- and m-region genotypes significantly differed between the north and south parts of the Middle East countries (P < 0.001). The vacA genotypes significantly increased the risk of gastric cancer (odds ratio [OR]: 4.02, 95% confidence interval [CI]: 1.98-8.14 for the s1 genotype; 2.50, 1.62-3.85 for m1; 5.27, 1.97-14.1 for s1m1; 15.03, 4.69-48.17 for i1) and peptic ulcers (OR: 3.07, 95% CI: 2.08-4.52 for s1; 1.81, 1.36-2.42 for m1). The cagA-positive genotype frequently coincided with the s1, m1 and i1 genotypes. The vacA s- and m-region genotypes may be useful risk factors for gastrointestinal diseases in the Middle East, similar to European and American countries. Further studies will be required to evaluate the effects of the i-region genotype.

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Conflict of interest statement

No conflicts of interest exist in this manuscript.

Figures

Fig. 1
Fig. 1
The proportions of vacA s, m and i genotypes in different Middle Eastern populations; the frequencies of vacA s, m and i genotypes significantly differed among the individual countries of the Middle East
See this image and copyright information in PMC

References

    1. Perez-Perez GI, Taylor DN, Bodhidatta L, Wongsrichanalai J, Baze WB, Dunn BE, et al. Seroprevalence of Helicobacter pylori infections in Thailand. J Infect Dis. 1990;161(6):1237–1241. - PubMed
    1. Rocha GA, Queiroz DM, Mendes EN, Oliveira AM, Moura SB, Barbosa MT, et al. Indirect immunofluorescence determination of the frequency of anti-H. pylori antibodies in Brazilian blood donors. Braz J Med Biol Res. 1992;25(7):683–689. - PubMed
    1. Souto FJ, Fontes CJ, Rocha GA, de Oliveira AM, Mendes EN, Queiroz DM. Prevalence of Helicobacter pylori infection in a rural area of the state of Mato Grosso, Brazil. Mem Inst Oswaldo Cruz. 1998;93(2):171–174. - PubMed
    1. Sandikci MU, Doran F, Koksal F, Sandikci S, Uluhan R, Varinli S, et al. Helicobacter pylori prevalence in a routine upper gastrointestinal endoscopy population. Br J Clin Pract. 1993;47(4):187–189. - PubMed
    1. Massarrat S, Saberi-Firoozi M, Soleimani A, Himmelmann GW, Hitzges M, Keshavarz H. Peptic ulcer disease, irritable bowel syndrome and constipation in two populations in Iran. Eur J Gastroenterol Hepatol. 1995;7(5):427–433. - PubMed

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