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Case Reports
. 2009 Dec;25(12):1627-31.
doi: 10.1007/s00381-009-0926-3. Epub 2009 Jun 25.

Ultrastructural evidence of ependymal differentiation in a genetically proven atypical teratoid/rhabdoid tumor

Manila Antonelli  1 , Giovanna Cenacchi, Piergiorgio Modena, Isabella Morra, Marco Forni, Felice Giangaspero
Affiliations
Case Reports

Ultrastructural evidence of ependymal differentiation in a genetically proven atypical teratoid/rhabdoid tumor

Manila Antonelli et al. Childs Nerv Syst. 2009 Dec.

Abstract

Introduction: We describe a case of genetically proven atypical teratoid/rhabdoid tumor (ATRT), showing ultrastructural evidence of ependymal differentiation. Such differentiation has not been reported so far in ATRT.

Conclusion: This finding supports the concept that ATRTs as the majority of central nervous system embryonal tumors may derive from an immature and pluripotent neuroectodermal cell capable of differentiating along multiple lineages.

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