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Randomized Controlled Trial
. 2009 Jun 28;15(24):3032-7.
doi: 10.3748/wjg.15.3032.

Improving quality of colonoscopy by adding simethicone to sodium phosphate bowel preparation

Sasinee Tongprasert  1 , Abhasnee Sobhonslidsuk, Sasivimol Rattanasiri
Affiliations
Randomized Controlled Trial

Improving quality of colonoscopy by adding simethicone to sodium phosphate bowel preparation

Sasinee Tongprasert et al. World J Gastroenterol. .

Abstract

Aim: To evaluate the effectiveness of simethicone in enhancing visibility and efficacy during colonoscopy.

Methods: A prospective, double-blind, randomized, placebo-controlled study was conducted. One hundred and twenty-four patients were allocated to receive 2 doses of sodium phosphate plus 240 mg of tablet simethicone or placebo as bowel preparation. Visibility was blindly assessed for the amount of air bubbles and adequacy of colon preparation. Total colonoscopic time, side effects of the medication, endoscopist and patient satisfaction were also compared.

Results: Sodium phosphate plus simethicone, compared to sodium phosphate plus placebo, improved visibility by diminishing air bubbles (100.00% vs 42.37%, P < 0.0001) but simethicone failed to demonstrate improvement in adequacy of colon preparation (90.16% vs 81.36%, P = 0.17). Endoscopist and patient satisfaction were increased significantly in the simethicone group. However, there was no difference in the total duration of colonoscopy and side effects of the medication.

Conclusion: The addition of simethicone is of benefit for colonoscopic bowel preparation by diminishing air bubbles, which results in enhanced visibility. Endoscopist and patient satisfaction is also increased.

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Patient disposition.
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References

    1. Toledo TK, DiPalma JA. Review article: colon cleansing preparation for gastrointestinal procedures. Aliment Pharmacol Ther. 2001;15:605–611. - PubMed
    1. Wexner SD, Beck DE, Baron TH, Fanelli RD, Hyman N, Shen B, Wasco KE. A consensus document on bowel preparation before colonoscopy: prepared by a task force from the American Society of Colon and Rectal Surgeons (ASCRS), the American Society for Gastrointestinal Endoscopy (ASGE), and the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) Gastrointest Endosc. 2006;63:894–909. - PubMed
    1. Belsey J, Epstein O, Heresbach D. Systematic review: oral bowel preparation for colonoscopy. Aliment Pharmacol Ther. 2007;25:373–384. - PubMed
    1. Burke CA, Church JM. Enhancing the quality of colonoscopy: the importance of bowel purgatives. Gastrointest Endosc. 2007;66:565–573. - PubMed
    1. Chiu HM, Lin JT, Wang HP, Lee YC, Wu MS. The impact of colon preparation timing on colonoscopic detection of colorectal neoplasms--a prospective endoscopist-blinded randomized trial. Am J Gastroenterol. 2006;101:2719–2725. - PubMed

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