Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2009 Jun 30;54(1):69-76.
doi: 10.1016/j.jacc.2009.03.016.

Contrast-enhanced whole-heart coronary magnetic resonance angiography at 3.0-T: a comparative study with X-ray angiography in a single center

Qi Yang  1 , Kuncheng Li, Xin Liu, Xiaoming Bi, Zhi Liu, Jing An, Al Zhang, Renate Jerecic, Debiao Li
Affiliations
Comparative Study

Contrast-enhanced whole-heart coronary magnetic resonance angiography at 3.0-T: a comparative study with X-ray angiography in a single center

Qi Yang et al. J Am Coll Cardiol. .

Erratum in

  • J Am Coll Cardiol. 2009 Nov 10;54(20):1902

Abstract

Objectives: The purpose of this study was to prospectively evaluate the diagnostic performance of 3.0-T contrast-enhanced whole-heart coronary magnetic resonance angiography (CMRA) in patients with suspected coronary artery disease (CAD).

Background: A slow-infusion, contrast-enhanced whole-heart CMRA approach has recently been developed at 3.0-T. The accuracy of this technique has not yet been determined among patients with suspected CAD.

Methods: The 3.0-T contrast-enhanced whole-heart CMRA was performed in 69 consecutive patients. An electrocardiography-triggered, navigator-gated, inversion-recovery prepared, segmented gradient-echo sequence was used to acquire isotropic whole-heart CMRA with slow infusion of 0.2 mmol/kg gadobenate dimeglumine. The diagnostic accuracy of whole-heart CMRA in detecting significant stenoses (> or =50%) was evaluated using X-ray angiography as the reference.

Results: The CMRA examinations were successfully completed in 62 patients. Acquisition time of whole-heart CMRA procedure was 9.0 +/- 1.9 min. The 3.0-T whole-heart CMRA correctly identified significant CAD in 32 patients and correctly ruled out CAD in 23 patients. The sensitivity, specificity, and accuracy of whole-heart CMRA for detecting significant stenoses were 91.6% (87 of 95), 83.1% (570 of 686), and 84.1% (657 of 781), respectively, on a per-segment basis. These values were 94.1% (32 of 34), 82.1% (23 of 28), and 88.7% (55 of 62), respectively, on a per-patient basis.

Conclusions: Contrast-enhanced whole-heart CMRA with 3.0-T allows for the accurate detection of coronary artery stenosis with high sensitivity and moderate specificity.

PubMed Disclaimer

Figures

Figure 1
Figure 1. Flow chart of patient inclusion
CAD = Coronary Artery Disease. CMRA = Magnetic Resonance Coronary Angiography.
Figure 2
Figure 2. 3T contrast-enhanced whole-heart CMRA images of a 71 year-old woman with normal coronary arteries
A. Volume rendered (VR) image providing an overview of coronary anatomy, clearly depicts RCA, LAD and diagonal branches. B. Curved MPR image using CoronaViz software shows LM, LAD, LCX and RCA
Figure 2
Figure 2. 3T contrast-enhanced whole-heart CMRA images of a 71 year-old woman with normal coronary arteries
A. Volume rendered (VR) image providing an overview of coronary anatomy, clearly depicts RCA, LAD and diagonal branches. B. Curved MPR image using CoronaViz software shows LM, LAD, LCX and RCA
Figure 3
Figure 3. 3T contrast-enhanced whole-heart CMRA images of a 54 year-old female patient
MIP image (A) of MRA detects a significant stenosis in the middle RCA (arrow) with good correlation with x-ray angiography (B). Both readers interpreted this as significant stenosis based on CMRA images.
Figure 3
Figure 3. 3T contrast-enhanced whole-heart CMRA images of a 54 year-old female patient
MIP image (A) of MRA detects a significant stenosis in the middle RCA (arrow) with good correlation with x-ray angiography (B). Both readers interpreted this as significant stenosis based on CMRA images.
Figure 4
Figure 4. 3T contrast-enhanced whole-heart CMRA images of a 75 year-old male patient with atypical chest pain
CMRA MIP images (A and B) show a significant stenosis in the proximal LCX and a non-significant stenosis in the middle RCA (arrows), respectively. VR images (syngo InSpace, Siemens AG Healthcare, Erlangen, Germany) (C and D)have the same findings in LCX and RCA, which were consistent with the conventional coronary angiography (E and F).
Figure 4
Figure 4. 3T contrast-enhanced whole-heart CMRA images of a 75 year-old male patient with atypical chest pain
CMRA MIP images (A and B) show a significant stenosis in the proximal LCX and a non-significant stenosis in the middle RCA (arrows), respectively. VR images (syngo InSpace, Siemens AG Healthcare, Erlangen, Germany) (C and D)have the same findings in LCX and RCA, which were consistent with the conventional coronary angiography (E and F).
Figure 4
Figure 4. 3T contrast-enhanced whole-heart CMRA images of a 75 year-old male patient with atypical chest pain
CMRA MIP images (A and B) show a significant stenosis in the proximal LCX and a non-significant stenosis in the middle RCA (arrows), respectively. VR images (syngo InSpace, Siemens AG Healthcare, Erlangen, Germany) (C and D)have the same findings in LCX and RCA, which were consistent with the conventional coronary angiography (E and F).
Figure 4
Figure 4. 3T contrast-enhanced whole-heart CMRA images of a 75 year-old male patient with atypical chest pain
CMRA MIP images (A and B) show a significant stenosis in the proximal LCX and a non-significant stenosis in the middle RCA (arrows), respectively. VR images (syngo InSpace, Siemens AG Healthcare, Erlangen, Germany) (C and D)have the same findings in LCX and RCA, which were consistent with the conventional coronary angiography (E and F).
Figure 4
Figure 4. 3T contrast-enhanced whole-heart CMRA images of a 75 year-old male patient with atypical chest pain
CMRA MIP images (A and B) show a significant stenosis in the proximal LCX and a non-significant stenosis in the middle RCA (arrows), respectively. VR images (syngo InSpace, Siemens AG Healthcare, Erlangen, Germany) (C and D)have the same findings in LCX and RCA, which were consistent with the conventional coronary angiography (E and F).
Figure 4
Figure 4. 3T contrast-enhanced whole-heart CMRA images of a 75 year-old male patient with atypical chest pain
CMRA MIP images (A and B) show a significant stenosis in the proximal LCX and a non-significant stenosis in the middle RCA (arrows), respectively. VR images (syngo InSpace, Siemens AG Healthcare, Erlangen, Germany) (C and D)have the same findings in LCX and RCA, which were consistent with the conventional coronary angiography (E and F).
See this image and copyright information in PMC

Comment in

References

    1. Lieberman JM, Botti RE, Nelson AD. Magnetic resonance imaging of the heart. Radiol Clin North Am. 1984;22(4):847–858. - PubMed
    1. Paulin S, von Schulthess GK, Fossel E, Krayenbuehl HP. MR imaging of the aortic root and proximal coronary arteries. AJR Am J Roentgenol. 1987;148(4):665–670. - PubMed
    1. Kim WY, Danias PG, Stuber M, Flamm SD, Plein S, Nagel E, Langerak SE, Weber OM, Pedersen EM, Schmidt M, Botnar RM, Manning WJ. Coronary magnetic resonance angiography for the detection of coronary stenoses. N Engl J Med. 2001;345(26):1863–1869. - PubMed
    1. Deshpande VS, Shea SM, Laub G, Simonetti OP, Finn JP, Li D. 3D magnetization-prepared true-FISP: A new technique for imaging coronary arteries. Magn Reson Med. 2001;46(3):494–502. - PubMed
    1. Pruessmann KP, Weiger M, Scheidegger MB, Boesiger P. SENSE: sensitivity encoding for fast MRI. Magn Reson Med. 1999;42(5):952–962. - PubMed

Publication types